4 There is also ample scientific evidence suggesting cross-reactivity between different pollens and raw fruits and vegetables.

So if you're allergic to molds, you may very well react to foods like mushrooms that contain a similar protein. Piperacillin-tazobactam – Similarly, allergic reaction specific to tazobactam is rare but possible. Cross-reactivity means that there are similar proteins shared between certain foods and certain molds. Consider penicillin skin-testing +/- amoxicillin challenge. penicillin allergy doesnt exist The term penicillins refers to four general groups of antibiotics, as shown below. Amoxicillin–clavulanate – patients who have a true IgE-mediated hypersensitivity to this drug combination may have an allergy to the clavulanate component, but not amoxicillin or other beta-lactam antibiotics. This provides a background for understanding the cross-reactivity of various beta-lactams. This opens the door to using beta-lactam antibiotics safely in patients who have had an allergic reaction to one or more of these drugs. In these patients, use clinical judgement and caution when prescribing any new antimicrobial. munologic cross-reactivity because penicillin-allergic patients have an increased incidence of hypersensitivity reactions to drugs immunologically unrelated. Emerging evidence shows that there is no such thing as a 'penicillin allergy' or 'cephalosporin allergy.' Instead, cross-allergic reactions are restricted to much smaller groups of antibiotics that share greater structural similarity. NB: Be aware that some patients may react to other β-lactams not because of cross-reactivity but because of their underlying predisposition to develop allergic reactions to multiple unrelated drugs (multiple drug allergy syndrome). drug rash with eosinophilia & systemic symptoms (DRESS) Cross-reactivity among penicillins and cephalosporins is attributed to similarity in side chains.Avoid all β-lactam antibiotics if documented severe non-lgE-mediated reaction to penicillin:

Penicillin allergy cross reactivity